Allied-Bristol Life Sciences Launches iβeCa Therapeutics from NYU School of Medicine to Develop Novel Cancer Therapeutics Targeting the Wnt Pathway
- Cancer therapeutics known as Inhibitors of Beta-Catenin Responsive Transcription (iCRTs) provide an approach to potential therapy for a number of hard-to-treat cancers
BOSTON (March 16, 2016) - Allied-Bristol Life Sciences, LLC (ABLS), a biopharmaceutical enterprise jointly owned between Allied Minds (LSE: ALM) and Bristol-Myers Squibb Company (NYSE: BMY), announced that it has launched a new subsidiary, iβeCa Therapeutics, to license proprietary compounds from NYU School of Medicine that target the Wnt signalling pathway. The Wnt pathway plays a key role in the development and progression of a number of cancers affecting large numbers of patients. iβeCa Therapeutics will focus on further discovery and development activities needed to identify candidates for human clinical testing.
Developed by Dr. Ramanuj Dasgupta, Research Associate Professor at NYU School of Medicine, and NYU’s drug discovery accelerator, the Office of Therapeutics Alliances (OTA), these Inhibitors of β-Catenin Responsive Transcription (iCRTs), are able to reduce tumour growth by inhibiting the Wnt signalling pathway that is functioning abnormally in tumour cells. The iCRTs were specifically identified and optimized to selectively inhibit the function of oncogenic, nuclear Beta-catenin while sparing its other, non-oncogenic activities.
“We are very excited to begin working with ABLS,” said Dr. Dasgupta. “Our work is at a critical point in its translation, where the resources and expertise of the ABLS team will make the difference in bringing these novel cancer therapies to patients as quickly as possible.”
“The OTA model is to de-risk select NYU drug discovery projects in an efficient and robust manner in order to fit the investment criteria of industry, and ultimately enhance our Office of Industrial Liaison’s ability to ink successful, licensing partnerships. iβeCa Therapeutics is a great example of how promising early academic projects can be advanced to attract highly qualified partners such as ABLS,” said Dr. Nadim Shohdy, Director of OTA.
“Dr. Dasgupta and OTA’s approach provides ABLS via iβeCa Therapeutics with the opportunity to identify new drug candidates for this pathway that has to date been quite challenging,” said Dr. Satish Jindal, Chief Executive Officer of ABLS. “We are eager to work with NYU on this program. This proprietary technology is at an ideal stage for us, allowing ABLS to utilise its significant drug discovery and development expertise to accelerate the pre-clinical research needed to bring these promising leads to clinical candidates.”
The licensing agreement with NYU School of Medicine is the third in a series of discovery and development projects that Allied-Bristol Life Sciences is pursuing. The license to this technology will be held by iβeCa Therapeutics, a new ABLS subsidiary specifically formed to complete further research and pre-clinical characterization so that a development candidate can be advanced to IND-enabling studies and beyond.
For more information about Allied-Bristol Life Sciences, please visit www.ablifescience.com.
For more information about the NYU Office of Therapeutics Alliances, please visit http://www.nyulmc.org/ota
For further information, please contact:
Allied-Bristol Life Sciences
Donna See, VP, Allied Minds Tel. +1-617-419-1800
Citigate Dewe Rogerson
Rob Newman Tel: +44(0)2076389571
About Allied-Bristol Life Sciences
Allied-Bristol Life Sciences (ABLS) is a jointly owned enterprise between Allied Minds and Bristol-Myers Squibb Company. Based upon compelling biological discoveries and insights from scientists at leading U.S. research institutions, ABLS identifies, sources and de-risks promising, early-stage therapeutic opportunities, from discovery through pre-clinical development, in key therapeutic areas, including fibrosis, cardiovascular diseases, oncology, immune-sciences, and genetically defined diseases. For more information, visit www.ablifescience.com.
About NYU Office of Therapeutics Alliances and NYU Office of Industrial Liaison
The NYU Office of Therapeutics Alliances (OTA) was created in 2013 to accelerate and de-risk drug discovery projects developed at NYU School of Medicine. The NYU Office of Industrial Liaison (OIL) promotes the commercial development of NYU discoveries and actively seeks commercial partners for licensing and research collaborations. Over the past ten years NYU has ranked first among all universities in income from technology licensing. For more information, please visit www.nyulmc.org/ota and http://oil.med.nyu.edu/.
About Allied Minds
Allied Minds (LSE: ALM) is an innovative U.S. science and technology development and commercialization company. Operating since 2006, Allied Minds forms, funds, manages and builds products and businesses based on innovative technologies developed at leading U.S. universities and federal research institutions. Allied Minds serves as a diversified holding company that supports its businesses and product development with capital, central management and shared services. More information about the Boston-based company can be found at www.alliedminds.com.
About Bristol-Myers Squibb
Bristol-Myers Squibb is a global pharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. For more information about Bristol-Myers Squibb, visit www.bms.com, or follow us on Twitter at http://twitter.com/bmsnews.
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